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fachmedien.de - spezialisierte Fachinformationen für Studium und Beruf
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Crohn's Disease and Ulcerative Colitis

From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach

Medium: Buch
ISBN: 978-1-4614-0997-7
Verlag: Springer US
Erscheinungstermin: 24.01.2012
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The conditions of Crohn’s disease and ulcerative colitis are excellent examples of how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient’s quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies are sometimes complex and associated with important risks requiring a deeper understanding of their molecular principles from clinicians.

Crohn’s Disease and Ulcerative Colitis serves as a unique combined resource for physicians and scientists addressing the needs of both groups. It will stimulate exchange and collaboration and shorten the path between discovery and application of new knowledge and also help clinicians understand new therapeutic concepts from their origins. This volume provides an introduction to mucosal immunology which forms the basis of modern immunotherapy. It also serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy as well as conventional and complex immunomodulatory principles. Each chapter is written by experts in their field and includes the most up to date information. Crohn’s Disease and Ulcerative Colitis will be of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis and related autoimmune disorders.

Produkteigenschaften

  • Artikelnummer: 9781461409977
  • Medium: Buch
  • ISBN: 978-1-4614-0997-7
  • Verlag: Springer US
  • Erscheinungstermin: 24.01.2012
  • Sprache(n): Englisch
  • Auflage: 1. Auflage 2012
  • Produktform: Gebunden
  • Gewicht: 2187 g
  • Seiten: 754
  • Format (B x H): 178 x 254 mm
  • Ausgabetyp: Kein, Unbekannt
  • Nachauflage: 978-3-319-33701-2

Themen

Autoren/Hrsg.

Herausgeber

Section 1: Epidemiology

Ch. 1: The genetics of inflammatory bowel disease Grace N. Gathungu Judy H. Cho

Ch. 2: Environmental factors in the epidemiology of inflammatory bowel disease Morten H. Vatn

Section 2: Immunobiology

Ch. 3: The intestinal immune system in health Per Brandtzaeg

Ch. 4: Understanding the epithelial barrier in inflammatory bowel disease Emily M. Bradford Emily S. Turner Jerrold R. Turner Ch. 5: Intestinal microbiology and ecology in inflammatory bowel disease Alan Walker

Ch. 6: Microbial recognition and pathogen-associated molecular pattern (PAMP) receptors in inflammatory bowel disease Kenya Honda, Koji Atarashi Junko Nishio

Ch. 7: Inflammasomes in inflammatory bowel disease Till Strowig Richard Flavell

Ch. 8: Antimicrobial peptides in inflammatory bowel disease Charles L. Bevins

Ch. 9: Vascular responses to intestinal inflammation in inflammatory bowel disease D. Neil Granger Norman R. Harris

Ch. 10: Immunobiology of dendritic cells in inflammatory bowel disease Daniel C. Baumgart

Ch. 11: Immunobiology of T-Cells in inflammatory bowel disease Scott B. Snapper Deanna D. Nguyen

Ch. 12: Immunobiology of B-Cells in inflammatory bowel disease Atsushi Mizoguchi Atul K. Bhan

Ch. 13: Immunobiology of monocytes and macrophages in inflammatory bowel disease Kevin J. Woollard

Ch. 14: Immunobiology of epithelial cells in inflammatory bowel disease Stephanie Dahan Vera Kandror Denmark Lloyd Mayer

Ch. 15: The Th1, Th2 and Th17 paradigm in inflammatory bowel disease Yasuhiro Nemoto Mamoru Watanabe

Ch. 16: Preclinical studies using mouse models of inflammatory bowel disease Fridrik Karlsson Iurii Koboziev Matthew B. Grisham

Section 3: Diagnostic Approach

Ch. 17: Enhanced endoscopy in inflammatory bowel disease Ralf Kiesslich

Ch. 18: MRI in Inflammatory Bowel Disease Patrik Rogalla Tanya Chawla

Ch. 19: CT in inflammatory bowel disease Joel G. Fletcher

Ch. 20: Ultrasound in inflammatory bowel disease Clemens Agné Michael Gebel

Ch. 21: Laboratory evaluation including novel diagnostic markers of inflammatory bowel disease Iris Dotan Ch. 22: Histology and pathology of inflammatory bowel disease Nora E. Joseph Christopher R. Weber

Ch. 23: Activity indices based assessment of disease activity in inflammatory bowel disease Edouard Louis Catherine Van Kemseke Catherine Reenaers

Ch. 24: Endoscopic assessment of disease activity and mucosal healing in inflammatory bowel disease Haruhiko Ogata Toshifumi Hibi

Ch. 25: Evaluation of quality of life in inflammatory bowel disease Pia Munkholm Natalia Pederesen

Section 4: Therapy

Ch. 26: The natural history of inflammatory bowel disease Charles N. Bernstein

Ch. 27: Conventional medical management of Crohn’s disease: sulfasalazine Miquel A. Gassull Eduard Cabré

Ch. 28: Conventional medical management of Crohn’s disease: corticosteroids A. Hillary Steinhart

Ch. 29: Conventional medical management of Crohn’s disease: azathioprine and 6-mercaptopurine Gil Kaplan Lloyd Sutherland

Ch. 30: Conventional medical management of Crohn’s Disease: Methotrexate Eoin Storan Laurence Egan

Ch. 31: Biologic Tr