Verkauf durch Sack Fachmedien

Blann

Blood Cancer

The genetics of aetiology, diagnosis and management

Medium: Buch
ISBN: 978-1-394-36285-1
Verlag: John Wiley & Sons Inc
Erscheinungstermin: 08.10.2026
vorbestellbar, Erscheinungstermin ca. Oktober 2026

Essential Genetic Insight for Accurate Blood Cancer Diagnosis and Care

Blood cancers are complex and heterogeneous, driven by chromosomal and genetic abnormalities that shape both development and clinical behaviour. Blood Cancer: The Genetics of Aetiology, Diagnosis and Management brings molecular pathology to the forefront, linking aetiology, laboratory investigation and treatment strategies across leukaemia, lymphoma and myeloma within a UK healthcare context.

Written by established writer, practitioner and researcher Andrew Blann, this text guides readers from foundational principals to applied clinical practice. Beginning with the constituents and formation of blood, it introduces key laboratory molecular pathology techniques before exploring myeloid and lymphoid malignancies in depth. Later chapters focus on diagnostic genetic markers and evolving treatment modalities, including immunotherapy, molecular therapies, and stem cell transplantation.

This integrated resource helps readers connect laboratory science with bedside decision-making, clarifying how abnormal genes and chromosomes underpin classification, prognosis and targeted therapy. Features include:

- Clear explanations of molecular pathology techniques used in modern haematology and oncology laboratories
- In-depth discussion of hallmark genetic markers such as the Philadelphia chromosome and their diagnostic significance
- Coverage of contemporary treatment approaches, from chemotherapy to advanced immunotherapies
- Richly illustrated diagrams, tables, and clinical images to simplify complex concepts

Designed for undergraduate and postgraduate students in medicine, biomedical clinical science, pathology, haematology, and oncology, Blood Cancer: The Genetics of Aetiology, Diagnosis and Management also supports advanced practitioner nurses, pharmacists, biomedical scientists, and clinicians seeking authoritative guidance on blood cancer genetics.


Produkteigenschaften


  • Artikelnummer: 9781394362851
  • Medium: Buch
  • ISBN: 978-1-394-36285-1
  • Verlag: John Wiley & Sons Inc
  • Erscheinungstermin: 08.10.2026
  • Sprache(n): Englisch
  • Auflage: 1. Auflage 2026
  • Produktform: Kartoniert
  • Seiten: 208
  • Ausgabetyp: Kein, Unbekannt
Autoren/Hrsg.

Autoren

Preface xi 1 Introduction to Blood Cancer 11.1 Fundamental Aspects of Blood 11.2 Tools for Investigating Blood Cancer 61.2.1 Haematology 61.3 A Historical Perspective of Blood Cancer 111.4 The Molecular Pathology of Cancer 151.5 Chapter Summary 23 2 Methods in Molecular Pathology 242.1 First-generation Techniques 252.2 Next-generation Sequencing 322.3 Third-generation Sequencing 392.4 Chapter Summary 42 3 Molecular Pathology of the Myeloid Lineage: Part 1 433.1 The Classification of Myeloid Neoplasms 443.2 Acute Myeloid Leukaemia (AML) 463.3 Acute Promyelocytic Leukaemia (APL) 503.4 Chronic Myeloid Leukaemia (CML) 513.5 Chronic Neutrophilic Leukaemia (CNL) 533.6 Myelomonocytic Leukaemia (MML) 533.7 Monocytic Leukaemia 553.8 Histiocytic/Dendritic Cell Neoplasms 553.9 Chapter Summary 57 4 Molecular Pathology of the Myeloid Lineage: Part 2 594.1 Eosinophilic, Basophilic and Mast Cell Neoplasms 594.2 Myelofibrosis and Myelodysplastic Neoplasms 614.3 The Erythroid Lineage 644.4 The Megakaryocyte Lineage 674.5 The Molecular Pathology of PV, MF and ET 704.6 Chapter Summary 71 5 Molecular Pathology of the Lymphoid Lineage 735.1 Lymphomas 735.2 Lymphocytic Leukaemias 775.3 Myeloma and Related Conditions 825.4 Chapter Summary 865.5 A Summary of Molecular Pathology of the Blood Cancers 87 6 An Introduction to Clinical Blood Cancer 896.1 Presentation of the Patient 896.2 Leading Diagnostic Tools 916.3 Treatments of Blood Cancer 956.4 Chapter Summary 101 7 Diagnosis and Management of Myeloid Neoplasms 1027.1 The Aetiology of Myeloid Neoplasms Revisited 1027.2 Acute Myeloid Leukaemia (AML) 1037.3 Acute Promyelocytic Leukaemia (APL) 1087.4 Chronic Myelocytic Leukaemia (CML) 1107.5 Chronic Neutrophilic Leukaemia (CNL) 1127.6 Eosinophilic, Basophilic and Mast Cell Neoplasms 1137.7 Monocytic Leukaemia 116Contents ix7.8 Myelomonocytic Leukaemia (MML) 1187.9 Histiocytic and Related Neoplasms 1207.10 Myelofibrosis and Myelodysplastic Neoplasms (MDS) 1227.11 The Erythroid Lineage 1247.12 The Megakaryocyte Lineage 1267.13 Chapter Summary 127 8 Diagnosis and Management of Lymphoid Neoplasms 1298.1 General Concepts in Lymphoma 1298.2 Hodgkin Lymphoma 1318.3 Non-Hodgkin Lymphoma (NHL) 1328.4 Acute Lymphoblastic Leukaemia (ALL) 1388.5 Chronic Lymphocytic Leukaemia (CLL) 142x Contents8.6 Myeloma and Related Conditions 1468.7 Chapter Summary 153 References 153Case Study 154Multiple Choice Questions 166Answers to Multiple Choice Questions 174Appendix A: Analysis of Genes and Chromosomal Abnormalities 178Subject Index 181Genes Index 185Fused Genes 189Chromosomal Abnormalities 190