Bone Marrow Transplantation

Bone marrow transplantation has emerged as a major form of treatment for a broad range of human diseases. Marrow transplantation has many unique biologic features and its principles differ markedly from the transplantation of solid organs. This volume overviews the present status of bone marrow transplantation and summarizes recent progress and controversies. Ad­ vances in defining the underlying biology of marrow transplantation are discussed. The current status of several major clinical problem areas are reviewed, including engraftment, acute and chronic graft-versus-host dis­ ease, immunodeficiency, and opportunistic infections. The therapeutic role of allogeneic and autologous bone marrow transplantation is discussed, and results are compared with alternative therapies.