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Cobley / Davison

Oxidative Eustress in Exercise Physiology

Medium: Buch
ISBN: 978-0-367-50877-7
Verlag: CRC Press
Erscheinungstermin: 26.08.2024
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Oxidative Eustress in Exercise Physiology unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e. it may be possible to maximise the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration and cancer. An international team of researchers documents the importance of redox biology in health and disease, especially when exercise is a clinically useful tool for the treatment of many diseases and conditions.

Features

- Defines essential redox biology reactions and concepts in exercise physiology

- Assesses key redox parameters in an in vivo human exercise context

- Identifies the challenges, opportunities and boundaries of current knowledge

- Includes a critique of the underlying mechanisms

- Summarises examples of translationally important research relating to disease states

Related Titles

Draper, N. & H. Marshall. Exercise Physiology for Health and Sports Performance (ISBN 978-0-2737-7872-1)

Wackerhage, H., ed. Molecular Exercise Physiology: An Introduction (ISBN 978-0-4156-0788-9)

Produkteigenschaften

  • Artikelnummer: 9780367508777
  • Medium: Buch
  • ISBN: 978-0-367-50877-7
  • Verlag: CRC Press
  • Erscheinungstermin: 26.08.2024
  • Sprache(n): Englisch
  • Auflage: 1. Auflage 2024
  • Serie: Oxidative Stress and Disease
  • Produktform: Kartoniert, Paperback
  • Gewicht: 467 g
  • Seiten: 242
  • Format (B x H x T): 178 x 254 x 13 mm
  • Ausgabetyp: Kein, Unbekannt

Themen

Autoren/Hrsg.

Herausgeber

1. Introduction to Oxidative (Eu)stress in Exercise Physiology.2. Measuring Oxidative Damage and Redox Signalling: Principles, Challenges, and Opportunities. 3. Exercise Redox Signalling: From ROS Sources to Widespread Health Adaptation. 4. Oxygen transport: a redox O2dyssey. 5. Mitochondrial redox regulation in adaptation to exercise. 6. Basal Redox Status Influences the Adaptive Redox Response to Regular Exercise. 7. Time to 'couple' redox biology with exercise immunology. 8. Exercise and RNA oxidation. 9. Exercise and DNA Damage: Considerations for the Nuclear and Mitochondrial Genome. 10. Nutritional Antioxidants for Sports Performance. 11. Antioxidant supplements and exercise adaptations. 12. Nitric oxide biochemistry and exercise performance in humans: influence of nitrate supplementation. 13. (Poly)phenols in exercise performance and recovery - more than an antioxidant? 14. Exercise: a strategy to target oxidative stress in cancer. 15. Oxidative Stress and Exericse Tolerance in Cystic Fibrosis. 16. Ageing, Neurodegeneration and Alzheimer's Disease - The Underlying Role Of Oxidative Distress. Richard J Elsworthy and Sarah Aldred. 17. Exercise, Metabolism and Oxidative Stress in the Epigenetic Landscape. Gareth W. Davison and Colum P. Walsh.