This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.
The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPa and CPß), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.
Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
Produkteigenschaften
- Artikelnummer: 9789811374494
- Medium: Buch
- ISBN: 978-981-13-7449-4
- Verlag: Springer
- Erscheinungstermin: 26.11.2019
- Sprache(n): Englisch
- Auflage: 1. Auflage 2019
- Produktform: Gebunden, HC runder Rücken kaschiert
- Gewicht: 348 g
- Seiten: 101
- Format (B x H x T): 160 x 241 x 13 mm
- Ausgabetyp: Kein, Unbekannt
Themen
- Medizin | Veterinärmedizin
- Medizin | Public Health | Pharmazie | Zahnmedizin
- Medizinische Fachgebiete
- Medizinische Parasitologie
- Medizin | Veterinärmedizin
- Medizin | Public Health | Pharmazie | Zahnmedizin
- Medizinische Fachgebiete
- Medizinische Parasitologie
