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Nicholas

Introduction to Veterinary Genetics

Medium: Buch
ISBN: 978-1-394-33150-5
Verlag: John Wiley & Sons Inc
Erscheinungstermin: 24.12.2026
vorbestellbar, Erscheinungstermin ca. Dezember 2026

The essential textbook on genetics and genomics for veterinary and animal science

Introduction to Veterinary Genetics, now in its fourth edition, provides students and practitioners with a solid grounding in genetics and genomics in the context of veterinary medicine and animal production.

This edition incorporates revisions throughout, including advances in molecular technology and updated approaches to the diagnosis and control of inherited disease. Coverage spans basic genetics and genomics, population and quantitative genetics and genomics. A new chapter covers cancer genetics and genomics.

Readers will also find: - Updated material on molecular technology advances reflecting current methods used in veterinary genetic diagnostics and research
- Coverage linking genetics and genomics concepts directly to animal production systems
- Discussion of parasites and pathogens from a genetic perspective, connecting host genetics to disease susceptibility and resistance
- End-of-chapter summaries in every chapter designed to support structured revision and efficient exam preparation
- Consistent terminology and coherent progression across all topics in the text

Introduction to Veterinary Genetics serves veterinary students, animal science students, and practicing veterinarians who need a reliable reference on genetic and genomic principles. Whether used as a course textbook aligned with veterinary medicine curricula or as a practitioner’s desk reference, this Fourth Edition provides the updated, authoritative coverage required for informed clinical and breeding decisions.


Produkteigenschaften


  • Artikelnummer: 9781394331505
  • Medium: Buch
  • ISBN: 978-1-394-33150-5
  • Verlag: John Wiley & Sons Inc
  • Erscheinungstermin: 24.12.2026
  • Sprache(n): Englisch
  • Auflage: 4. Auflage 2026
  • Produktform: Kartoniert
  • Seiten: 384
  • Ausgabetyp: Kein, Unbekannt
  • Vorauflage: 978-1-4051-6832-8
Autoren/Hrsg.

Autoren

Preface

Acknowledgements

1 Basic genetics

Chromosomes

Meiosis and mitosis

The biochemistry of inheritance

What is a gene?

Gene regulation

Mutation

Simple or Mendelian inheritance

Linkage

Inactivation

Types of DNA

Summary

Websites

Further reading

Appendix 1.1 Banded karyotypes of domestic species

2 Molecular biology

Restriction enzymes

DNA cloning and Recombinant DNA

DNA sequencing

Complementary DNA

RNA sequencing

Polymerase chain reaction (PCR)

Microsatellites

Single nucleotide polymorphisms (SNPs)

Gene mapping

Reference genome assemblies

Whole-genome sequencing (WGS)

Whole-exome sequencing (WES)

Beyond SNP chips

Comparative genomics

Production of polypeptide from cloned DNA

Transgenesis

Antisense technology

CRISPR-Cas

Summary

Websites

Further reading

3 Single-gene disorders

Inborn errors of metabolism

Sex-limited inheritance

Genetic heterogeneity of disease

Type of gene action and type of disease

Phenocopies

Congenital and non-congenital disorders

A sample of single-gene disorders

A revolution in identifying the likely causal

variant of single-gene disorders

Summary

Websites

Further reading

Appendix 3.1 Online Mendelian Inheritance in Animals (OMIA): a compendium of single-gene traits and their likely causal variants

4 Chromosomal aberrations

Abnormal chromosome number

Abnormal chromosome structure

Chromosomal aberrations in cancer

Evolution of karyotypes

Interspecific hybridization

Freemartins

Biological basis of sex

Classification of intersex

A sample of chromosomal aberrations

Summary

Further reading

Appendix 4.1 A sample of chromosomal aberrations in animals

5 Single genes in populations

Allele and genotype frequencies

Random mating

The Hardy–Weinberg law

Extensions to the Hardy–Weinberg law

Selection and mutation

Genetic drift and the founder effect

Extending population genetics to more than one locus

Summary

Websites

Further reading

6 Familial disorders not due to a single gene

Liability and threshold

The multifactorial model

More than one threshold

Heritability

Penetrance and expressivity

Future resolution of multiple factors

Recurrence risks

Summary

Further reading

7 Is it inherited?

General evidence for a genetic aetiology

The four types of simple, Mendelian inheritance

Studying and analysing the data

Summary

Websites

Further reading

8 Immunogenetics

Antibodies

Red-cell antigens

The major histocompatibility complex (MHC)

Summary

Websites

Further reading

9 Pharmacogenetics and Pharmacogenomics

Genetic polymorphisms affecting drug reaction

Genetics and anaesthesia

Warfarin resistance

Multifactorial pharmacogenetics

Summary

Websites

Further reading

10 Hosts, parasites, and pathogens

Host–pathogen interactions

Resistance in hosts

Resistance in parasites and pathogens

Control of parasites and pathogens

Increasing the level of resistance in hosts

Increasing the level of resilience in hosts

Summary

Websites

Further reading

11 Single genes in animal breeding

Coat colour

Carpet wool

Prolificacy in sheep

Polledness

Muscular hypertrophy in cattle and sheep

Dwarf poultry

Genes for sexing chickens

Parentage testing

Summary

Websites

Further reading

12 Relationship and inbreeding

The inbreeding coefficient

Relationship

Genomic relationship

The inbreeding coefficient revisited

General expressions for relationship and inbreeding

The base population

Inbreeding in populations

Runs of homozygosity

Inbreeding depression

Summary

Websites

Further reading

13 Quantitative variation

Quantitative traits

The performance of an individual animal

The differences between animals

Heritability

Correlations between traits

Quantitative trait loci (QTL)

Summary

Websites

Further reading

14 Selection between populations

Comparison between populations

Genotype–environment interaction

Comparing breeds of companion animals

Further reading

15 Selection within populations

Estimated breeding values and accuracy of selection

Phenotypic clues to a candidate’s breeding value for a trait

Combining clues from more than one source

Best linear unbiased prediction (BLUP)

Correlated traits

Selection for more than one trait

The importance of inbreeding and genetic drift

Genomic selection

Polygenic Risk Scores: genomic clues to a candidate’s phenotypic value

Ultimate genotypes

Summary

Websites

Further reading

16 Breed structure

The traditional pyramid

Closed-nucleus breeding schemes

Open-nucleus breeding schemes

Community-based breeding programmes

Summary

Websites

Further reading

17 Crossing

Regular crossing

Crossing to produce a synthetic

Designer dogs

Grading-up

Summary

Websites

Further reading

18 Selection and regular crossing

Selection

Selection and regular crossing

Summary

Further reading

19 Biotechnology

Artificial insemination (AI)

Multiple ovulation and embryo transfer (MOET)

In vitro maturation (IVM) and in vitro fertilization

(IVF) of ova

Control of sex ratio

Recombinant proteins

Transgenesis

Uses of CRISPR-Cas

Animal cloning

Animal forensics

Barcode of life

Summary

Websites

Further reading

20 Conservation genetics

Measurement of genetic diversity within populations

Measurement of genetic diversity among populations

Importance of genetic diversity

Loss of genetic diversity

Conservation of genetic diversity

Targeted genetic intervention

Summary

Websites

Further reading

21 Genetic and environmental control of inherited disorders

Environmental control of inherited disorders

Genetic control of single-gene disorders

Genetic control of multifactorial disorders

Genetic control – some final points

Crossing: thinking outside the square

Summary

Websites

Further reading

22 Cancer genetics and genomics

Mutational basis of cancer

Genome screens of cancers

Genetic variation in susceptibility to cancer

Summary

Websites

Further reading

Index