Verkauf durch Sack Fachmedien

Sazanov

A Structural Perspective on Respiratory Complex I

Structure and Function of NADH:ubiquinone oxidoreductase

Medium: Buch
ISBN: 978-94-007-4137-9
Verlag: Springer
Erscheinungstermin: 16.05.2012
Lieferfrist: bis zu 10 Tage

The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.


Produkteigenschaften


  • Artikelnummer: 9789400741379
  • Medium: Buch
  • ISBN: 978-94-007-4137-9
  • Verlag: Springer
  • Erscheinungstermin: 16.05.2012
  • Sprache(n): Englisch
  • Auflage: 1. Auflage 2012
  • Produktform: Gebunden, HC runder Rücken kaschiert
  • Gewicht: 612 g
  • Seiten: 286
  • Format (B x H x T): 160 x 241 x 21 mm
  • Ausgabetyp: Kein, Unbekannt
Autoren/Hrsg.

Herausgeber

Part I: Structure and mechanism of complex I. - 1. Structure of complex I. - 2. On the mechanism of the respiratory complex I. - 3. Iron–sulfur clusters in complex I. - 4. Current Topics of the Inhibitors of Mitochondrial Complex I. - 5. My Fifty Years Association with Complex I Study. - Part II:Evolution of complex I. - 6. The Evolutionary Relationship between Complex I and [NiFe]-hydrogenase. - 7. Recruitment of the antiporter module - a key event in complex I evolution. - Part III:Mutations in complex I subunits and medical implications. - 8. Characterization of Bacterial Complex I (NDH-1) by a Genetic Engineering Approach. - 9. Cellular consequences of mtDNA-encoded mutations in NADH:ubiquinone oxidoreductase. - Part IV:Subunit composition and assembly of mitochondrial complex I. - 10. The assembly of human complex I. - 11. Complexes I in the green lineage. - Part V:Supercomplexes in mitochondria. - 12.  Supramolecular organization of the respiratory chain.