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Tolnay / Probst

Neuropathology and Genetics of Dementia

Medium: Buch
ISBN: 978-0-306-46558-1
Verlag: Springer Us
Erscheinungstermin: 31.05.2001
Lieferfrist: bis zu 10 Tage

these "tauopathies" are reviewed by Delacourte. Therecentdiscoverythatmutationsofthetaugenearecausativeforfamilial formsoffrontotemporaldementiaandParkinsonism(FTDP-17)broughtthe "taupathway"and the"tauopathies"tothecentrestage.Thisextraordinary breakthroughwillbecoveredbySpillantiniandGoedert.Thereisincreasing evidence that argyrophilic grain disease is much more frequent in older patients than previously thought. Tolnay et al. are reviewing recent contributionstothepathologyofthislate-onsetdementingdisorderinwhich ofamyloidbetadeposits,isalmost taupathology,inthealmosttotalabsence exclusivelyrestricted to the limbic lobe and the amygdala. Schultzet al. report an intriguing age-related progression of neuronal and glial tau pathologyinbaboonsthusrenderingthe baboonapotentialprimatemodel forage-relatedhuman"tauopathies". Gotzetal. introducetransgenicmice expressingmutated human tau as valuable animal models for reproducing formationofneuro-andglialfibrillarylesions.


Produkteigenschaften


  • Artikelnummer: 9780306465581
  • Medium: Buch
  • ISBN: 978-0-306-46558-1
  • Verlag: Springer Us
  • Erscheinungstermin: 31.05.2001
  • Sprache(n): Englisch
  • Auflage: 2001. Auflage 2001
  • Serie: Advances in Experimental Medicine and Biology
  • Produktform: Gebunden
  • Gewicht: 1620 g
  • Seiten: 255
  • Format (B x H x T): 178 x 254 x 16 mm
  • Ausgabetyp: Kein, Unbekannt

Themen


Autoren/Hrsg.

Herausgeber

Can the Physician Predict the Neuropathologist?.- The Molecular Parameters Of Tau Pathology.- Tau as a killer and a witness.- Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17.- Argyrophilic Grain Disease.- A frequent dementing disorder in aged patients.- Tau Pathology in Neurons and Glial Cells of Aged Baboons.- Human Tau Transgenic Mice.- Towards an animal model for neuro-and glialfibrillary lesion formation.- Regulation of Alzheimer 13-Amyloid Precursor Trafficking and Metabolism.- Role of Type 10 1713-Hydroxysteroid Dehydrogenase in the Pathogenesis of Alzheimer’s Disease.- The Spectrum Of Vascular Disease In Dementia.- From ischemia to amyloid angiopathy.- Transgenic Mouse Models of Cerebral Amyloid Angiopathy.- Alpha-Synuclein.- Axonal transport, ligand interaction and neurodegeneration.- Dementia with Lewy Bodies.- Mouse Models of ?-Synucleinopathy and Lewy Pathology.- ?-synuclein expression in transgenic mice.- Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases.- Perisomatic Granules of Hippocampal CA1 Neurons in Alzheimer’s Disease, Pre-Alzheimer Stage and Pick’s Disease: an Overlooked Pathological Entity.- Ubiquitin and the Molecular Pathology of Neurodegenerative Diseasespathological Mechanisms in Polyglutamine Expansion Diseases.- Dementia in the Neuronal Ceroid-Lipofuscinoses.- Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis.- Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageing.