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van der Laan / Dudoit

Multiple Testing Procedures with Applications to Genomics

Medium: Buch
ISBN: 978-1-4419-2379-0
Verlag: Springer
Erscheinungstermin: 25.11.2010
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This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.


Produkteigenschaften


  • Artikelnummer: 9781441923790
  • Medium: Buch
  • ISBN: 978-1-4419-2379-0
  • Verlag: Springer
  • Erscheinungstermin: 25.11.2010
  • Sprache(n): Englisch
  • Auflage: 1. Auflage. Softcover version of original hardcover Auflage 2008
  • Serie: Springer Series in Statistics
  • Produktform: Kartoniert, Previously published in hardcover
  • Gewicht: 931 g
  • Seiten: 590
  • Format (B x H x T): 155 x 235 x 34 mm
  • Ausgabetyp: Kein, Unbekannt
Autoren/Hrsg.

Autoren

Multiple Hypothesis Testing.- Test Statistics Null Distribution.- Overview of Multiple Testing Procedures.- Single-Step Multiple Testing Procedures for Controlling General Type I Error Rates, ?(Fvn).- Step-Down Multiple Testing Procedures for Controlling the Family-Wise Error Rate.- Augmentation Multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Resampling-Based Empirical Bayes multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Simulation Studies: Assessment of Test Statistics Null Distributions.- Identification of Differentially Expressed and Co-Expressed Genes in High-Throughput Gene Expression Experiments.- Multiple Tests of Association with Biological Annotation Metadata.- HIV-1 Sequence Variation and Viral Replication Capacity.- Genetic Mapping of Complex Human Traits Using Single Nucleotide Polymorphisms: The ObeLinks Project.- Software Implementation.