This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
Produkteigenschaften
- Artikelnummer: 9781441923790
- Medium: Buch
- ISBN: 978-1-4419-2379-0
- Verlag: Springer
- Erscheinungstermin: 25.11.2010
- Sprache(n): Englisch
- Auflage: 1. Auflage. Softcover version of original hardcover Auflage 2008
- Serie: Springer Series in Statistics
- Produktform: Kartoniert, Previously published in hardcover
- Gewicht: 931 g
- Seiten: 590
- Format (B x H x T): 155 x 235 x 34 mm
- Ausgabetyp: Kein, Unbekannt
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