Noradrenergic Signaling and Astroglia

Robert Zorec, Ph.D., Professor of Pathophysiology at the University of Ljubljana, Faculty of Medicine, a Full Member of Academia Europaea (London) and Slovenian Academy of Sciences and Arts (continuation of Academia Operosorum Labacensis from 1693), as well as a past Member of the Committee for Advanced Therapy at the European Medicines Agency (London). He received his Ph.D. from the University of Ljubljana in 1986 for his work conducted at the Newcastle Medical School and at the MRC Neuroendocrinology Unit in Newcastle upon Tyne, UK, in Dr. R.N. McBurney's laboratory studying single-channel chloride currents activated by GABA and glycine in spinal cord neurons. He introduced the patch-clamp technique in Ljubljana in 1985. Dr. Zorec's post-doctoral experience was at Cambridge, UK, in Dr. W.T. Mason's laboratory. Independently of the laboratory of the Nobel Laureate, Erwin Neher, he developed his own membrane capacitance measurements (MCM) to monitor processes such as endo-and exocytosis in real time. In Prof. M. Berridge's laboratory at Cambridge University (UK), he studied cytosolic calcium homeostasis by imaging related to the MCM approach. In 1991, he conducted experiments on plant secretory cells at the University of Adelaide, Australia. He used his MCM technique to study regulated exocytosis in skeletal muscle, taste cells, neurons, and glia. Since 1991, he has been Head of the Laboratory of Neuroendocrinology-Molecular Cell Physiology and in 1997 he received the Republic of Slovenia Prize for Science. In 2000, he established the Cell Engineering Laboratory at Celica Biomedical, Ljubljana Tech Park (http://celicabiomedical.com/) where he has been a CEO since 2006 and the head of the Carl Zeiss Reference Center for Confocal Microscopy. Recently, his laboratory has developed research on astrocytes, the most heterogeneous neuroglial cells in the brain, to learn how vesicle traffic and regulated exocytosis are altered in these cells under pathologic conditions. In addition to MCM, super-resolution fluorescence microscopy has been developed in his laboratory to study subcellular vesicle traffic and more than 160 peer-reviewed papers have been published. He has lectured at over 100 distinguished universities, international meetings, and research institutions worldwide. He has been a reviewer for leading scientific journals including Nature, Science, PNAS, Neuron, Journal of Neuroscience, Journal of Physiology, Biophysical Journal, Brain Research, and others. In addition to basic research, the laboratory is also developing advanced cell-based medicines such as hybridoma cells to treat cancer; one product, HybriCure, is currently in phase 1/2 clinical trials.